Synthesis of prazole compounds
AssigneeCodexis, Inc.
InventorsYong Koy Bong, Michael D. Clay, Steven J. Collier, Benjamin Mijts, Michael Vogel, Xiyun Zhang, Jun Zhu, Jovana Nazor, Derek Smith, Shiwei Song
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Abstract
The present disclosure relates to non-naturally occurring monooxygenase polypeptides useful for preparing prazole compounds, polynucleotides encoding the polypeptides, and methods of using the polypeptides.
Claims11
A non-naturally occurring monooxygenase, wherein said monooxygenase comprises a polypeptide sequence having at least 90% identity to SEQ ID NO:124, and wherein said monooxygenase is capable of converting 5-methoxy-2-((4-methoxy-3,5-dimethylpyridin-2-yl)methylthio)-1H-benzo[d]imidazole (“compound (1)”) to 5-methoxy-2-((4-methoxy-3,5-dimethylpyridin-2-yl)methylsulfinyl)-1H-benzo[d]imidazole (“compound (2)”), and wherein said polypeptide sequence
- has two or more residue differences as compared to SEQ ID NO:2 at the following residue positions:
- position corresponding to X246;
- position corresponding to position corresponding to X248;
- position corresponding to X326;
- position corresponding to X386;
- position corresponding to X432;
- position corresponding to X433;
- position corresponding to X435;
- position corresponding to X438;
- and position corresponding to X448.
Dependencies are inferred from the claim text.