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US 8,895,263 B2Granted
Methods for suppressing toll-like receptor activity
AssigneeJanssen Biotech, Inc.
InventorsJarrat Jordan, Sun-Yung Jung, Robert T. Sarisky, Jessica Schreiter
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Abstract
Agents interfering with translocation of Toll-like receptor 3 (TLR3), methods of making and using the foregoing are disclosed.
Claims6
A method of interfering with translocation of toll-like receptor 3 (TLR3) in vitro, comprising transfecting into a cell expressing TLR3 a cDNA that encodes an agent that interferes with translocation of TLR3, wherein the agent is a TLR3 variant comprising a polypeptide having the amino acid sequence shown in SEQ ID NO:
- 1 or SEQ ID NO:
- 2.
Dependencies are inferred from the claim text.