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US 8,895,257 B2Granted
Proteins used for the diagnosis of lyme borreliosis
AssigneeBiomerieux
InventorsLionel Levet, Odile Mejan-Letourneur
Life of this patent
Estimating the term…
Abstract
Chimera proteins including: (i) at least one sequence of a VlsE protein of a Borrelia species selected from B. garinii, B. burgdorferi sensu stricto and B. afzelii, and (ii) at least one sequence including sequences of the IR6 domain of B. burgdorferi sensu stricto, B. afzelii and B. garinii. Also, a method and a kit for the in vitro diagnosis of Lyme borreliosis using said proteins.
Claims15
A chimeric protein comprising:
- (i) at least one amino acid sequence having at least 50% sequence identity with any of the amino acid sequences selected from the group consisting of SEQ ID NOS:
- 1-5;
- and
- (ii) at least one amino acid sequence having at least 80% sequence identity with any of the amino acid sequences selected from the group consisting of SEQ ID NOS:
- 6-8,
- wherein the chimeric protein comprises at least one amino acid sequence of (i) and at least one amino acid sequence of (ii) that are from different Borrelia strains or species.
3 more elements
Dependencies are inferred from the claim text.