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US 8,895,254 B2Granted
Biomarkers for ankylosing spondylitis
AssigneeUniversity Health Network
InventorsFlorence Wing Ling Tsui, Robert Davies Inman
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Abstract
There is described herein methods and peptides for detecting autoantibodies to NOG and/or SOST in a patient sample in order to diagnose of prognosticate Ankylosing Spondylitis in the patient.
Claims15
A method for diagnosing a subject with Ankylosing Spondylitis comprising:
- a. providing a sample from the subject suspected having Ankylosing Spondylitis;
- b. detecting a level of autoantibodies to at least one of Noggin (NOG) and Sclerostin (SOST) in the sample;
- c. comparing the level of autoantibodies detected in b. to a level of autoantibodies in a control sample;
- wherein a relatively higher level of autoantibodies in the subject sample compared to the control sample is indicative of Ankylosing Spondylitis in the subject.
1 more element
A method for prognosticating Ankylosing Spondylitis in a subject comprising:
- a. providing a sample from the subject;
- b. detecting a level of autoantibodies to at least one of NOG and SOST in the sample;
- c. comparing the level of autoantibodies detected in b. to a level of autoantibodies in a control sample;
- wherein a relatively higher level of autoantibodies in the subject sample compared to the control sample is at least one of (i) indicative of the likelihood of the subject to have progression in ankylosis and (ii) a predictor of severity of disease.
1 more element
Dependencies are inferred from the claim text.