Integrin heterodimer and a subunit thereof
AssigneeXintela AB
InventorEvy Lundgren-Akerlund
Life of this patent
Estimating the term…
Abstract
A recombinant or isolated integrin heterodimer comprising a novel subunit α10 in association with a subunit β is described. The α10 integrin may be purified from bovine chondrocytes on a collagen-type-II affinity column. The integrin or the subunit of α10 can be used as a marker or target of all types of cells, e.g. of chondrocytes, osteoblasts, and fibroblasts. The integrin or the subunit α10 thereof can be used as a marker or target in different physiological or therapeutic methods. They can also be used as active ingredients in pharmaceutical compositions and vaccines.
Claims18
A method of detecting a population of mammalian integrin subunit alpha10-expressing cells, said method comprising the steps of:
- a) contacting an integrin subunit alpha10-expressing cell population with an antibody or a fragment thereof capable of binding to a fragment of the integrin subunit alpha10, wherein said integrin subunit alpha10 consists of amino acids 23-1167 of SEQ ID NO:4, and
- b) detecting said cell population binding to said antibody,
- thereby detecting a population of mammalian integrin subunit alpha10-expressing cells.
A method of selecting a population of integrin subunit alpha10-expressing cells, said method comprising the steps of:
- a) contacting integrin subunit alpha10-expressing cells with an antibody or a fragment thereof capable of binding to a fragment of the integrin subunit alpha10, wherein said integrin subunit alpha10 consists of amino acids 23-1167 of SEQ ID NO:4,
- b) separating cells binding to said antibody or fragment thereof, and optionally
- c) isolating and purifying the separated cells,
- thereby producing a population of integrin subunit alpha10-expressing cells.
Dependencies are inferred from the claim text.