High energy radiation insensitive analyte sensors

An enzyme-based analyte sensor comprising at least one enzyme and at least one non-fugitive radiation stabilizing agent

• wherein the radiation stabilizing agent comprises at least one of a hindered amine light stabilizer, a polymeric hindered phenol, a polymeric aromatic amine, a polymer with thioester or phosphorous containing appendages, a polymeric hydroxyl amine, a polymeric benzofuranone derivative, and polymeric acrylated bis-phenol,
• wherein the molecular weight of the radiation stabilizing agent is greater than about 1000 Daltons and the radiation stabilizing agent is present in an amount sufficient to stabilize the activity of the at least one enzyme when the sensor is subjected to high energy radiation.