Liquid composition of cisplatin coordination compound
AssigneesNanocarrier Co., Ltd., The University of Tokyo
InventorsKazunori Kataoka, Nobuhiro Nishiyama, Chieko Tsuchiya, Tatsuyuki Hayashi
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Abstract
A liquid composition containing a polymer micelle and having a pH values of 3.0 to 7.0 is provided. The micelle is constituted of a coordination compound having a block copolymer of polyethylene glycol and polyglutamic acid and cisplatin that is coordinate-bonded to the block copolymer.
Claims15
A liquid composition, comprising a coordination compound of a block copolymer represented by the following formula I or formula II:
- wherein, R1 independently represents a hydrogen atom or alkyl group optionally substituted by a functional group or substituent, A independently represents NH, CO, R5(CH2)pR6 or a direct bond, wherein R5 represents O, OCO, OCONH, NHCO, NHCOO, NHCONH, CONH or COO, R6 represents NH or CO, and p represents an integer of 1 to 6, R2 independently represents a hydrogen atom or an alkali metal, R3 independently represents a hydrogen atom, hydroxyl group or hydrophobic residue, n represents an integer of 110 to 340, and m represents an integer of 20 to 80;
- and
- cisplatin, wherein the pH of the liquid composition is 4.0 to 6.0.
A liquid composition, comprising a coordination compound of a block copolymer represented by the following formula I or formula II:
- wherein, R1 represents a hydrophilic segment, A represents R5(CH2)pR6, wherein R5 represents O, R6 represents NH, and p represents an integer of 1 to 6, R2 represents a hydrogen atom or an alkali metal, R3 represents a hydrogen atom, n represents an integer of 200 to 340, and m represents an integer of 30 to 50;
- and
- cisplatin, wherein the pH of the liquid composition is 4.0 to 6.0.
A liquid composition, comprising a coordination compound formed from cisplatin and a methoxypolyethylene glycol-polyglutamic acid copolymer, wherein:
- the methoxypolyethylene glycol-polyglutamic acid copolymer has an average number of glutamic acid residues of 40,
- the glutamic acid residues have carboxylic acid side chains,
- one or both chlorine atoms of the cisplatin are replaced with carboxyl anions of the methoxypolyethylene glycol-polyglutamic acid copolymer
- and the pH of the liquid composition is 4.0 to 6.0.
Dependencies are inferred from the claim text.