Regional delivery of therapeutic agents for the treatment of vascular diseases

A method of treating a vascular disease, comprising:

• providing a device having a regional delivery interface comprising a therapeutic agent;
• contacting the regional delivery interface with a surface of a segment of a vessel that includes a region that is afflicted with a vascular disease, wherein:
• the regional delivery interface is at least about 40 mm in length, and the regional delivery interface contacts the vessel segment surface not only at the afflicted region but also at a non-afflicted region at the periphery of the afflicted region;
• and
• delivering the therapeutic agent onto or into the vessel segment surface from the regional delivery interface in contact with the vessel segment surface,
• wherein the therapeutic agent is delivered simultaneously to both the afflicted region and the non-afflicted region in a therapeutically effective amount and in a substantially uniform dose,
• wherein the therapeutic agent is provided in a pharmaceutically acceptable composition, and
• wherein the pharmaceutically acceptable composition comprises a micelle, a worm micelle, or a polymerosome.