Testosterone formulations

A transdermal or transmucosal formulation comprising:

• 2% wt of testosterone, 44.0% wt of ethanol, 20.0% wt of propylene glycol, and 5.0% wt of diethylene glycol monoethyl ether, wherein said formulation is substantially free of long-chain fatty alcohols, long-chain fatty acids, and long-chain fatty esters.

A transdermal or transmucosal formulation comprising:

• 2% wt of testosterone, 44.0% wt of ethanol, 20.0% wt of propylene glycol, 5.0% wt of diethylene glycol monoethyl ether, 1.20% wt of carbomer, 0.35% wt of triethanolamine, 0.06% wt of edetate disodium and water wherein said formulation is substantially free of long-chain fatty alcohols, long-chain fatty acids, and long-chain fatty esters.

A transdermal or transmucosal formulation consisting of 2% wt of testosterone, 44.0% wt of ethanol, 20.0% wt of propylene glycol, 5.0% wt of diethylene glycol monoethyl ether, 1.20% wt of carbomer, 0.35% wt of triethanolamine, 0.06% wt of edetate disodium and water.

A method of treating a disease or disorder associated with reduced endogenous testosterone production in a male subject comprising:

• transdermally administering to a skin or mucosal membrane of a male subject a formulation comprising:
• 1-2% wt of testosterone, C2 to C4 alkanol, 20.0% wt of propylene glycol, and monoalkyl ether of diethylene glycol, wherein said formulation is substantially free of long-chain fatty alcohols, long-chain fatty acids, and long-chain fatty esters.

A method of treating a disease or disorder associated with reduced endogenous testosterone production in a male subject comprising:

• transdermally administering to a skin or mucosal membrane of a male subject a formulation comprising:
• 1-2% wt of testosterone, C2 to C4 alkanol, 20.0% wt of propylene glycol, monoalkyl ether of diethylene glycol, gelling agent, neutralizing agent, chelating agent and solvent, wherein said formulation is substantially free of long-chain fatty alcohols, long-chain fatty acids, and long-chain fatty esters.

A method of treating a disease or disorder associated with reduced endogenous testosterone production in a male subject comprising:

• transdermally administering to a skin or mucosal membrane of a male subject a formulation comprising 1-2% wt of testosterone, 44% wt of ethanol, 20.0% wt of propylene glycol, 5% wt of monoethyl ether of diethylene glycol, 1.20% wt of carbomer, 0.35% wt of triethanolamine, 0.06% wt of edetate disodium and water wherein the formulation is substantially free of long-chain fatty alcohols, long-chain fatty acids, and long-chain fatty esters.

A method of treating a disease or disorder associated with reduced endogenous testosterone production in a male subject comprising:

• transdermally administering to a skin or mucosal membrane of a male subject a formulation consisting of 1-2% wt of testosterone, 44% wt of ethanol, 20.0% wt of propylene glycol, 5% wt of monoethyl ether of diethylene glycol, 1.20% wt of carbomer, 0.35% wt of triethanolamine, 0.06% wt of edetate disodium and water.