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US 8,895,049 B2Granted
Extended release biodegradable ocular implants
AssigneeAllergan, Inc.
InventorsThierry Nivaggioli, Jane Guo Shiah, Qing Lin
Life of this patent
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Abstract
Biodegradable implants sized and suitable for implantation in an ocular region or site and methods for treating ocular conditions. The implants provide an extended release of an active agent at a therapeutically effective amount for a period of time between 50 days and one year, or longer.
Claims5
A method for making an extended release bioerodible implant for treating an ocular condition, the method comprising the steps of:
- (a) blending an active agent with a first bioerodible polymer;
- (b) extruding the blend of step (a) to form a filament;
- (c) breaking the extruded filament of step (b) into particles with a size of between about 30 μm and about 50 μm;
- (d) blending additional quantities of the active agent with a second bioerodible polymer;
- (e) mixing the particles of step (c) with the blend of step (d):
- (f) extruding the mixture of step (e) to form a filament;
- (g) cutting the filament of step (f) to form an extended release bioerodible implant for insertion into an ocular region for treating an ocular condition.
4 more elements
Dependencies are inferred from the claim text.