Dendritic nano-antioxidants

A compound of General Formula I:

• wherein X is a multi-valent center selected from the group consisting of
• Y is selected from the group consisting of N and C;
• n is 2, if Y is N;
• and n is 3, if Y is C;
• m is 1 to 4;
• R is:
• wherein R0 is selected from the group consisting of a direct bond, alkylene, alkenylene, alkynylene, heteroalkylene, heteroalkenylene, heteroalkynylene, azidylene, —NR32— and heterogenous groups;
• and
• R32 is independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, heteroalkyl, heteroalkenyl, heteroalkynyl, aryl, heteroaryl, cycloalkyl and heterocycloalkyl;
• R1, R2, and R3 are independently selected from the group consisting of hydrogen, halo, —R4, and —O—R4,
• wherein R4 is selected from the group consisting of hydrogen, alkylamino, heteroalkyl, hydroxyalkyl, alkylazide, and —R6—N(R7)(R8);
• at least one of R1, R2, and R3 is —OH;
• R6 is selected from the group consisting of alkylene, alkenylene, alkynylene, heteroalkylene, heteroalkenylene, heteroalkynylene, azidylene, and heterogenous groups;
• and
• R7 and R8 are independently selected from the group consisting of hydrogen and —A,
• wherein A is
• wherein R9 is selected from the group consisting of a direct bond, alkylene, alkenylene, alkynylene, heteroalkylene, heteroalkenylene, heteroalkynylene, azidylene, —NR32— and heterogenous groups;
• R32 is independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, heteroalkyl, heteroalkenyl, heteroalkynyl, aryl, heteroaryl, cycloalkyl and heterocycloalkyl;
• and
• R10, R11, and R12 are independently selected from the group consisting of hydrogen, halo, —R13, and —O—R13,
• wherein R13 is selected from the group consisting of hydrogen, alkyl, alkylamino, heteroalkyl, hydroxyalkyl, alkylazide, alkenyl, and —R14—N(R15)(R16);
• and
• at least one of R10, R11, and R12 is —OH;
• R14 is selected from the group consisting of alkylene, alkenylene, alkynylene, heteroalkylene, heteroalkenylene, heteroalkynylene, azidylene and heterogenous groups;
• and
• R15 and R16 are independently selected from the group consisting of hydrogen and —B,
• wherein B is
• wherein R17 is selected from the group consisting of a direct bond, alkylene, alkenylene, alkynylene, heteroalkylene, heteroalkenylene, heteroalkynylene, azidylene, —NR32—, and heterogenous groups;
• R32 is independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, heteroalkyl, heteroalkenyl, heteroalkynyl, aryl, heteroaryl, cycloalkyl, and heterocycloalkyl;
• and
• R18, R19, and R20 are independently selected from the group consisting of hydrogen, halo, —R21, and —O—R21,
• wherein R21 is selected from the group consisting of hydrogen, alkyl, alkylamino, heteroalkyl, hydroxyalkyl, alkylazide, and alkenyl;
• and
• at least one of R18, R19, and R20 is —OH.