Interaction of Moraxella catarrhalis with epithelial cells, extracellular matrix proteins and the complement system
AssigneeArne Forsgren AB
InventorsArne Forsgren, Kristian Riesbeck
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Abstract
The present disclosure relates to surface proteins of Moraxella catarrhalis and their ability to interact with epithelial cells via cell-associated fibronectin and laminin, and also to their ability to inhibit the complement system. These surface proteins are useful in the preparation of vaccines. The present disclosure also provides peptides interacting with fibronectin, laminin and the complement system.
Claims8
An isolated polypeptide consisting of an amino acid sequence selected from SEQ ID NOs. 6, 7, and 8, or, a hydroxylation product, sulphonation product, or glycosylation product of said polypeptide that retains laminin-binding properties.
An isolated ligand consisting of a laminin-binding domain, said ligand consisting of an amino acid sequence selected from SEQ ID NOs. 6, 7, and 8, a hydroxylation product, sulphonation product, or glycosylation product of the amino acid sequence selected from SEQ ID NOs. 6, 7, and 8, wherein the ligand retains laminin-binding properties.
A polypeptide, consisting of SEQ ID NO:
- 6, 7, or 8, or a hydroxylation, sulphonation or glycosylation product of said polypeptide that retains the ability of binding laminin.
Dependencies are inferred from the claim text.