Sequences of brachyspira, immunogenic compositions, methods for preparation and use thereof
AssigneePrionics AG
InventorsDavid J. Hampson, Tom La, Matthew I. Bellgard, Nyree D. Phillips
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Abstract
Novel polynucleotide and amino acids of Brachyspira hyodysenteriae are described. These sequences are useful for diagnosis of B. hyodysenteriae disease in animals and as a therapeutic treatment or prophylactic treatment of B. hyodysenteriae disease in animals. These sequences may also be useful for diagnostic and therapeutic and/or prophylactic treatment of diseases in animals caused by other Brachyspira species.
Claims22
An isolated protein comprising an amino acid sequence that is at least 85% homologous to the amino acid sequence of SEQ ID NO 12, wherein the protein is fused to a heterologous polypeptide that permits the detection, isolation, solubilization or stabilization of the protein.
An immunogenic composition comprising an isolated protein comprising a sequence that is at least 95% homologous to the amino acid sequence of SEQ ID NO 12, wherein the protein is fused to a heterologous polypeptide that permits the detection, isolation, solubilization or stabilization of the protein.
Dependencies are inferred from the claim text.