US 8,895,017 B2 · HER-2 peptides and vaccines

Abstract

The present invention provides (a) isolated immunogenic HER-2 peptides capable of inducing immune responses against human HER-2 receptor; (b) isolated nucleic acid molecules encoding an isolated immunogenic HER-2 peptide; (c) plasmid constructs comprising a nucleic acid molecule encoding an isolated immunogenic HER-2 peptide; (d) vaccine compositions comprising an isolated immunogenic HER-2 peptide (e) vaccine compositions comprising an isolated nucleic acid molecule encoding an isolated immunogenic HER-2 peptide; and (f) methods of treating or preventing cancer, inhibiting abnormal cell proliferation, or eliciting an immune response against HER-2 protein in a mammal using (1) an isolated immunogenic HER-2 peptide, (2) nucleic acid molecule encoding an isolated immunogenic HER-2 peptide, or (3) a composition comprising an isolated immunogenic HER-2 peptide, or composition comprising a nucleic acid molecule encoding an isolated immunogenic HER-2 peptide.

Claims7

Dependent claims

An isolated immunogenic HER-2 peptide which comprises an ECD-derived peptide, wherein the ECD-derived peptide comprises an amino acid sequence that (i) is 90% to 100% identical to amino acids 23-645 of SEQ ID NO:

5 or 95% to 100% identical to amino acids 25-647 of SEQ ID NO:
14, (ii) comprises amino acid sequences of at least four of the conserved T cell epitopes in the ECD of human HER-2 protein, and (iii) is 70% to 95% identical to the amino acid sequence of the ECD of human HER-2 protein, and wherein the amino acid sequence of the human HER-2 protein is set forth in SEQ ID NO:
1.

Dependencies are inferred from the claim text.

HER-2 peptides and vaccines

Life of this patent

HER-2 peptides and vaccines

Life of this patent

Abstract

Claims7