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US 8,895,016 B2Granted
Antagonists of activin-actriia and uses for increasing red blood cell levels
AssigneeAcceleron Pharma Inc.
InventorsMatthew L. Sherman, Jasbir Seehra, Niels Borgstein
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Abstract
In certain aspects, the present invention provides compositions and methods for increasing red blood cell and/or hemoglobin levels in vertebrates, including rodents and primates, and particularly in humans.
Claims23
A method for treating anemia in a patient, the method comprising administering to a patient in need thereof an effective amount of an ActRIIa polypeptide selected from the group consisting of:
- a) a polypeptide comprising an amino acid sequence at least 95% identical to SEQ ID NO:
- 2;
- b) a polypeptide comprising an amino acid sequence at least 95% identical to SEQ ID NO:
- 3;
- c) a polypeptide comprising an amino acid sequence at least 95% identical to SEQ ID NO:
- 7;
- d) a polypeptide comprising an amino acid sequence at least 95% identical to SEQ ID NO:
- 12;
- and
- e) a polypeptide comprising an amino acid sequence that is encoded by a nucleic acid that hybridizes to the complement of SEQ ID NO:5 in the presence of 6.0 sodium/sodium citrate (SSC) at 45° C. followed by a wash in 2.0 SSC at 45° C., and
- wherein the ActRIIa polypeptide binds to activin.
8 more elements
Dependencies are inferred from the claim text.