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US 8,895,002 B2Granted
Hemojuvelin fusion proteins and uses thereof
AssigneeThe General Hospital Corporation
InventorsHerbert Y. Lin, Jodie Babitt, Clifford J. Woolf, Tarek A. Samad
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Abstract
The present invention provides a hemojuvelin (HJV) fusion protein (e.g., a human HJV.Fc) protein, polynucleotides and vectors encoding such proteins, and methods for making such proteins. Also provided are methods for treating iron-related disorders which include administration of a HJV fusion protein to a patient in need thereof.
Claims38
A fusion protein comprising:
- (a) a hemojuvelin (HJV) polypeptide or fragment thereof, wherein said polypeptide or fragment thereof has at least 95% amino acid sequence identity to a portion of the HJV protein of SEQ ID NOs:
- 2, 3 or 4 and is at least 50 amino acids in length;
- and
- (b) a first fusion partner, wherein said first fusion partner is conjugated to said HJV polypeptide or fragment thereof, wherein said first fusion partner is an IgG1 Fc;
- and
- (c) a second fusion partner.
3 more elements
Dependencies are inferred from the claim text.