Nitric oxide-releasing polymers
AssigneeAmulet Pharmaceuticals, Inc.
InventorsErnst V. Arnold, Blaine G. Doletski, Robert E. Raulli
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Abstract
This invention relates to compositions comprising carbon-based diazeniumdiolates attached to hydrophobic polymers that releases nitric oxide (NO). The carbon-based diazeniumdiolated polymers release NO spontaneously under physiological conditions without subsequence nitrosamine formation. The present invention also relates to methods of preparing the carbon-based diazeniumdiolated polymers, compositions comprising such polymers, methods of using such compositions, and devices employing such polymer compositions.
Claims20
A composition comprising a carbon-based diazeniumdiolate compound attached to at least one phenyl-containing polymer, and having the formula:
- R3—C(R1)x(N2O2R2)y
- wherein x is an integer from 0 to 2 and y is an integer from 1 to 3, and the sum of x plus y equals 3;
- wherein R1 is not an imidate or thioimidate;
- wherein R2 is selected from the group consisting of a countercation and a protecting group on the terminal oxygen;
- and
- wherein R3 is a phenyl of said phenyl-containing polymer.
A composition comprising a carbon-based diazeniumdiolate compound attached to at least one phenyl-containing polymer that comprises a polymer backbone, wherein the phenyl of said phenyl-containing polymer is pendant from the backbone of said polymer, and wherein said composition has the following general formula:
- wherein R1 not an imidate or thioimidate;
- and
- wherein R2 is selected from the group consisting of a countercation and a protecting group on the terminal oxygen.
Dependencies are inferred from the claim text.