Copolymer-associated nanomaterial
AssigneeMassachusetts Institute of Technology
InventorsWenhao Liu, Peter Matthew Allen, Numpon Insin, Moungi G. Bawendi
Life of this patent
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Abstract
A nanomaterial can include an outer layer including a ligand. The ligand can include a first monomer unit including a first moiety having affinity for a surface of the nanocrystal, a second monomer unit including a second moiety having a high water solubility, and a third monomer unit including a third moiety having a selectively reactive functional group or a selectively binding functional group. The ligand can be a random copolymer.
Claims9
A nanomaterial comprising:
- a nanocrystal;
- and
- an outer layer including a ligand, wherein the ligand includes a polymer including a random copolymer including regions of R1, R2, and R3, wherein:
- R1 has a formula -L1-T1, wherein L1 includes alkylene terminated by —CONH—, wherein T1 includes imidazole;
- R2 has a formula -L2-T2, wherein L2 includes alkylene terminated by —CONH—, wherein T2 includes —[O—CH2—CHR5]n—R6, where R5 is H, n is an integer in the range of 0 to 30, and R6 is C1 to C6 alkoxy;
- R3 has a formula -L3-T3, wherein L3 includes alkylene terminated by —CONH—, wherein T3 includes —[O—CH2—CHR7]m—R8, where R7 is H, m is an integer in the range of 0 to 30, and R8 is C1 to C6 aminoalkyl.
A method of making a ligand, comprising:
- mixing a first monomer or oligomer including R1;
- a second monomer or oligomer including R2;
- and a third monomer or oligomer including R3;
- wherein:
- R1 has a formula -L1-T1, wherein L1 includes alkylene terminated by —CONH—, wherein T1 includes imidazole;
- R2 has a formula -L2-T2 wherein L2 includes alkylene terminated by —CONH—, wherein T2 includes —[O—CH2—CHR5]n—R6, where R5 is H, n is an integer in the range of 0 to 30, and R6 is C1 to C6 alkoxy;
- R3 has the formula -L3-T3, wherein L3 includes alkylene terminated by —CONH—, wherein T3 includes —[O—CH2—CHR7]m—R8, where R7 is H, in is an integer in the range of 0 to 30, and R8 is C1 to C5 aminoalkyl;
- and
- forming a ligand from the first monomer oligomer, the second monomer or oligomer, and the third monomer oligomer.
A ligand including a polymer including a random copolymer including regions having each of the following formulae:
- wherein
- R1 has a formula -L1-T1, wherein L1 includes alkylene terminated by —CONH—, wherein T1 includes imidazole:
- R2 has the formula -L2-T2, wherein for L2 includes alkylene terminated by —CONH—, wherein T2 includes —[O—CH2—CHR5]n—R6, where R5 is H, n is an integer in the range of 0 to 30, and R6 is C1 to C6 alkoxy;
- R3 has the formula -L3-T3, wherein L3 includes alkylene terminated by —CONH—, wherein T3 includes —[O—CH2—CHR7]m—R8, where R7 is H, m is an integer in the range of 0 to 30, and R8 is C1 to C6 aminoalkyl;
- each of Ra, Rb, and Rc, independently, is substituted or unsubstituted alkyl, substituted or unsubstituted alkoxy, substituted or unsubstituted aryl, or substituted or unsubstituted aryloxy;
- and
- each of x, y, and z, independently, a positive integer.
Dependencies are inferred from the claim text.