Hepatic artery nerve modulation methods
AssigneeMetavention, Inc.
InventorsBobak Robert Azamian, Scott Bradley Vafai, Jonathan Allen Coe
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Abstract
According to some embodiments, a method of treating a subject having diabetes or symptoms associated with diabetes is provided. The method includes delivering a neuromodulation catheter within a vessel (e.g., hepatic artery) having surrounding nerves that innervate the liver (e.g., sympathetic nerves of the hepatic plexus). The method may also include modulating (e.g., disrupting, ablating, stimulating) the nerves by mechanical compression, energy delivery, or fluid delivery.
Claims20
A method of facilitating hepatic neuromodulation, comprising:
- inserting an energy delivery device within vasculature of a subject;
- intravascularly advancing a distal portion of the energy delivery device to a location within a portion of a hepatic artery;
- and
- delivering energy toward one or more nerves within or surrounding a wall of the hepatic artery sufficient to ablate the one or more nerves in a manner that facilitates a reduction in at least one of a blood glucose level or a lipoprotein level in the subject;
- and
- removing the energy delivery device from the subject.
A method of facilitating hepatic neuromodulation in a subject, comprising:
- inserting an energy delivery device into vasculature of a subject,
- wherein a distal portion of the energy delivery device comprises at least one electrode;
- advancing the distal portion of the energy delivery device to a location within a hepatic artery of the vasculature;
- and
- intravascularly modulating one or more sympathetic nerves located within or surrounding a wall of the hepatic artery using the energy delivery device,
- wherein the distal portion of the energy delivery device is configured to cause maintained contact of the at least one electrode with the wall of the hepatic artery during said modulating.
A method of facilitating hepatic neuromodulation in a subject, comprising:
- causing energy to be delivered by at least one energy delivery element of an energy delivery device positioned to deliver energy to one or more sympathetic nerves of a subject within or surrounding a wall of a hepatic artery,
- wherein the energy is delivered at a frequency in the range of 3 kHz to 300 GHz, and
- wherein the delivered energy is sufficient to disrupt neural communication of the one or more sympathetic nerves.
Dependencies are inferred from the claim text.