Systems, devices and methods for imaging and surgery

A system for imaging and ablation of biological tissue in a subject, comprising:

• an imaging light source configured to produce light for imaging of biological tissue;
• an air core optical delivery fiber having a core size;
• a relay lens system;
• a focusing lens coupling the laser light from the light source to the optical delivery fiber;
• an objective lens, wherein the optical delivery fiber is configured to direct light from the imaging light source through the relay lens system for transmission onto the objective lens, and wherein the objective lens is configured to direct light transmitted onto it from the imaging light source to a region of interest in the subject and to receive light from the region of interest;
• a photodetector configured to detect at least a portion of the light received from the region of interest;
• and
• an ultra-fast pulsed surgical laser light source configured to produce laser light with a pulse energy sufficient for ablation of biological tissue, wherein the pulse energies are 50 nanojoules (nJ) or higher and wherein the ultra-fast pulsed surgical laser light has a pulse duration of less than one nanosecond;
• wherein the coupled laser light having the pulse energies of 50 nanojoules (nJ) or higher and a pulse duration of less than one nanosecond is guided in a single mode in the optical delivery fiber,
• wherein a focus beam size of the laser light from the laser light source coupled to the optical delivery fiber is smaller than the core size of the fiber,
• wherein produced laser light having the pulse energies of 50 nanojoules (nJ) or higher and a pulse duration of less than one nanosecond is configured to be directed from the ultra-fast pulsed surgical laser light source to the objective lens, and
• wherein the objective lens is configured to transmit light having the pulse energies of 50 nanojoules (nJ) or higher and a pulse duration of less than one nanosecond from the ultra-fast surgical laser light source to a region of interest in the subject for ablation of biological tissue.

A system for surgical ablation and imaging in a subject, comprising:

• an imaging light source configured to produce laser light for imaging of biological tissue;
• an ultra-fast pulsed surgical laser light source configured to produce laser light with pulse energies sufficient for ablation of biological tissue;
• wherein the pulse energies are 50 nanojoules (nJ) or higher and wherein the ultra-fast pulsed surgical laser light has a pulse duration of less than one nanosecond;
• an air core optical delivery fiber having a core size, wherein a focused beam size of the light from the laser light source coupled to the optical delivery fiber is smaller than the core size of the fiber;
• a focusing lens coupling the laser light having pulse energies sufficient for ablation of biological tissue with pulse energies of 50 nJ or higher and a pulse duration of less than one nanosecond from the light source to the optical delivery fiber, wherein the light is guided in single mode;
• a microelectromechanical scanning device;
• a relay lens system;
• an objective lens, wherein the microelectromechanical scanning device is configured to direct light from the imaging and surgical laser light sources through the relay lens system for transmission onto the objective lens, and wherein the objective lens is configured to direct light transmitted onto it to a region of interest in the subject and to receive light from the region of interest;
• an optical transmitter in communication with the objective lens, wherein the optical transmitter is adapted to transmit at least a portion of the light received from the region of interest by the objective lens;
• and
• a photodetector in communication with the optical transmitter and configured to detect at least a portion of the light transmitted by the optical transmitter.

A device for surgical manipulation of biological tissue in a subject, comprising:

• an air core optical delivery fiber having a core size;
• a focusing lens coupling laser light having pulse energies of 50 nJ or higher and a pulse duration of less than one nanosecond from an ultra-fast pulsed surgical laser light source to the optical delivery fiber;
• and
• an objective lens, wherein the optical delivery fiber is configured to direct light having pulse energies of 50 nJ or higher and a pulse duration of less than one nanosecond from the ultra-fast pulsed surgical laser light source for transmission to the objective lens,
• wherein the laser light is guided in a single mode in the optical delivery fiber,
• wherein a focused beam size of the laser light from the laser light source coupled to the optical delivery fiber is smaller than the core size of the fiber,
• wherein the objective lens is configured to transmit light having pulse energies of 50 nJ or higher and a pulse duration of less than one nanosecond from the ultra-fast pulsed surgical laser light source directed to it to a region of interest in the subject for ablation of biological tissue in the subject.

A device for imaging and surgical manipulation of biological tissue in a subject, comprising:

• an air core optical delivery fiber having a core size;
• a relay lens system;
• a focusing lens coupling laser light from a light source to the optical delivery fiber;
• and
• an objective lens,
• wherein the optical delivery fiber is configured to direct light from an imaging light source through the relay lens system for transmission onto the objective lens,
• wherein the objective lens is configured to direct light transmitted onto it from the imaging light source to a region of interest in the subject and to receive light from the region of interest for imaging biological tissue,
• wherein the optical delivery fiber is further configured to direct surgical laser light from an ultra-fast pulsed surgical laser the directed surgical laser light from the ultra-fast pulsed surgical laser having pulse energies of 50 nJ or higher and a pulse duration of less than one nanosecond light source to the objective lens,
• wherein the surgical laser light is guided in a single mode in the optical delivery fiber,
• wherein a focused beam size of the surgical laser light from the laser light source coupled to the optical delivery fiber is smaller than the core size of the fiber,
• wherein the objective lens is configured to transmit surgical laser light from the surgical laser light source to a region of interest in the subject for ablation of biological tissue in the subject.