Self-destructing transdermal therapeutic system having improved functionality and efficacy
AssigneeLTS Lohmann Therapie-Systeme AG
InventorsStefan Maier, Margit Wirz
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Abstract
The invention relates to a self-destructing transdermal therapeutic system (TTS), preferably in the form of a transdermal patch, that includes an active ingredient, an agent rendering the active ingredient useless, and a perforation mechanism. The perforation mechanism allows a mobile phase to reach the agent that is capable of rendering the active ingredient useless after removing the TTS after use. The agent then comes into contact with the active ingredient and destroys the active ingredient in the presence of the mobile phase.
Claims11
A method of self-destroying a transdermal therapeutic system comprising
- providing a transdermal therapeutic system comprising at least one active ingredient, at least one agent which makes the active ingredient useless, at least one separation layer permeable to liquids but impermeable to solids between the active ingredient and the agent which makes the active ingredient useless, and at least one mechanical means for perforation adjacent a liquid impermeable layer, said mechanical means for perforation possessing a blunt outer contour and a sharp or pointed internal region,
- applying the transdermal therapeutic system to a patient's skin;
- removing the transdermal therapeutic system from the patient's skin and thereby perforating the liquid impermeable layer with the sharp or pointed internal region of the mechanical means for perforation, said perforating step ensuring that a mobile phase can approach the agent which makes the active ingredient useless, and
- contacting the active ingredient and the agent which makes the active ingredient useless with one another, thereby destroying the active ingredient by this contact.
A self-destructing transdermal therapeutic system comprising at least one active ingredient, at least one agent which makes the active ingredient useless, at least one separation between the active ingredient and the agent which makes the active ingredient useless, and at least one mechanical means for perforation, wherein said mechanical means for perforation possesses a blunt outer contour and a sharp or pointed internal region, said sharp or pointed internal region perforating the separation between the active ingredient and the agent which makes the active ingredient useless upon removal of the TTS after use, said perforation ensuring that a mobile phase can approach the agent which makes the active ingredient useless, thereby allowing the active ingredient and the agent which makes the active ingredient useless to come into contact with one another and destroy the active ingredient by this contact.
Dependencies are inferred from the claim text.