Activation of bone and cartilage formation
AssigneeKCI Licensing, Inc.
InventorLarry D. Swain
Life of this patent
Estimating the term…
Abstract
Provided is a method of activating osteogenic or chondrogenic activity at a site in a subject in need thereof. Also provided is a method of treating a bone or cartilage defect in a subject. Additionally, the use of a reduced pressure apparatus for treating a bone or cartilage defect adjacent to dura mater, periosteum, or endosteum is provided. Further provided is a composition for treating a bone or cartilage defect. Also, the use of a reduced pressure apparatus and a biocompatible scaffold for the manufacture of a composition for treating a bone or cartilage defect adjacent to dura mater, periosteum or endosteum is provided.
Claims16
A system for activating osteogenic or chondrogenic activity at a tissue site in a subject, the system comprising:
- a source of reduced pressure;
- and
- a manifold formed from an open-cell reticulated foam having pore sizes between about 400 microns and about 600 microns and adapted to be fluidly connected to the source and positioned adjacent dura mater for applying reduced pressure to the dura mater of the subject adjacent the tissue site in the subject;
- wherein the manifold is porous and formed from a flowable material that is deliverable through a manifold delivery tube to the tissue site such that the flowable material is adapted to fill the defect.
A system for treating a bone or cartilage defect in a subject, the system comprising:
- a source of reduced pressure;
- a manifold formed from an open-cell reticulated foam having pore sizes between about 400 microns and about 600 microns, fluidly connected to the source and adapted to be positioned adjacent dura mater for applying reduced pressure to the dura mater that is adjacent the defect;
- and
- a biocompatible scaffold configured to be inserted into the defect, the biocompatible scaffold formed of a bioresorable polymer having a polylactide-coglycolide (PLAGA) polymer or a polyethylene glycol-PLAGA copolymer.
A system for treating a bone or cartilage defect in a subject, the system comprising:
- a source of reduced pressure;
- a biocompatible scaffold adapted to be positioned into the defect, the biocompatible scaffold formed of a bioresorable polymer having a polylactide-coglycolide (PLAGA) polymer or a polyethylene glycol-PLAGA copolymer;
- and
- a manifold formed from an open-cell reticulated foam having pore sizes between about 400 microns and about 600 microns and adapted to be fluidly connected to the source of reduced pressure and positioned adjacent dura mater for applying reduced pressure to the dura mater adjacent the defect;
- wherein the manifold is porous and formed from a flowable material that is deliverable through a manifold delivery tube to the tissue site such that the flowable material is adapted to fill the defect.
Dependencies are inferred from the claim text.