Facially amphiphilic polymers as anti-infective agents

A polymer or oligomer of formula I

• wherein:
• A and B are o- or m-phenylene wherein one of A or B is substituted with a polar (P) group and a nonpolar (NP) group and the other of A or B is substituted with neither a polar (P) group nor a nonpolar (NP) group;
• s is C≡C—;
• R1 is (i) halo and R2 is hydrogen;
• or (ii)C-s-B-s- and R2 is C;
• or, (iii)C-s- and R2 is -A-s-C wherein C is pyridine or phenyl said pyridine or phenyl optionally substituted with 1 or 2 substituents independently selected from the group consisting of halo, nitro, cyano, C1-C6alkoxy, C1-C6alkoxycarbonyl, and benzyloxycarbonyl;
• NP is a nonpolar group independently selected from R4 or —U—(CH2)p—R4 wherein R4 is selected from the group consisting of hydrogen, C1-C10 alkyl, C3-C18 branched alkyl, C3-C8cycloalkyl, monocyclic or polycyclic phenyl optionally substituted with one or more C1-C4 alkyl or halo groups, and monocyclic or polycyclic heteroaryl optionally substituted with one or more C1-C4 alkyl or halo groups, and U and p are as defined below;
• P is a polar group selected from the group consisting of III, hydroxyethoxymethyl, methoxyethoxymethyl and polyoxyethylene
• —U—(CH2)p—V (III)
• wherein:
• U is absent or selected from the group consisting of O, S, S(═O), S(═O)2, NH, —C(═O)O—, —C(═O)NH—, —C(═O)S—, —C(═S)NH—, —S(═O)2NH—, and C(═NO—) wherein groups with two chemically nonequivalent termini can adopt both possible orientations;
• V is selected from the group consisting of amino, hydroxyl, C1-C6alkylamino, C1-C6dialkylamino, NH(CH2)pNH2, N(CH2CH2NH2)2, amidine, guanidine, semicarbazone, basic heterocycle, and phenyl optionally substituted with an amino, C1-C6alkylamino, C1-C6dialkylamino and lower acylamino optionally substituted with one or more amino, lower alkylamino or lower dialkylamino;
• and the alkylene chain is optionally substituted with an amino or hydroxyl group or unsaturated;
• p is independently 0 to 8;
• and,
• m is 2 to about 500.