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US 8,889,140 B2Granted
Compositions and methods for tissue repair
AssigneesTransTarget, Inc., The Regents of the University of California
InventorsRandall J. Lee, Shirley Mihardja, Manley Huang, James W. Larrick
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Abstract
The present invention provides compositions and methods for targeting an extracellular matrix derived (EMD) peptide predominantly to an injured tissue, as opposed to an uninjured tissue in vivo. The targeted EMD peptide facilitates the repair and/or regeneration of the injured tissue by providing a surface for cells to attach and grow, thereby facilitating the repair and/or regeneration of the injured tissue.
Claims5
A composition for repair of an injured tissue, the composition comprising
- an injury-associated antigen-specific binding component conjugated to an extracellular matrix derived (EMD) peptide,
- wherein the injury-associated antigen-specific binding component is an antibody that specifically binds myosin heavy chain and
- wherein the EMD peptide comprises a Hep III peptide comprising the sequence of SEQ ID NO:2, and exhibits the ability to:
- (i) activate cells;
- (ii) attach cells;
- and (iii) exhibits a chemotropic property.
3 more elements
Dependencies are inferred from the claim text.