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AssigneeWayne State University
InventorsRangaramanujam M. Kannan, Sujatha Kannan, Roberto Romero, Raghavendra S. Navath
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A nanodevice composition including N-acetyl cysteine linked to a dendrimer, such as a PAMAM dendrimer or a multiarm PEG polymer, is provided. Also provided is a nanodevice for targeted delivery of a compound to a location in need of treatment. The nanodevice includes a PAMAM dendrimer or multiarm PEG polymer, linked to the compound via a disulfide bond. There is provided a nanodevice composition for localizing and delivering therapeutically active agents, the nanodevice includes a PAMAM dendrimer or multiarm PEG polymer and at least one therapeutically active agent attached to the PAMAM dendrimer or multiarm PEG polymer. A method of site-specific delivery of a therapeutically active agent, by attaching a therapeutically active agent to a PAMAM dendrimer or multiarm PEG polymer using a disulfide bond, administering the PAMAM dendrimer or multiarm PEG polymer to a patient in need of treatment, localizing the dendrimer or multiarm PEG polymer to a site in need of treatment, and releasing the therapeutically active agent at the site in need of treatment.
A nanodevice composition comprising N-acetyl cysteine linked to a PAMAM dendrimer via disulfide bonds.
A nanodevice composition comprising N-acetyl cystine linked to a PAMAM dendrimer via one or more spacer compounds selected from the group consisting essentially of SPDP, Glutathione (GSH), Gamma-aminobutyric acid (GABA), and combination thereof.
A nanodevice for targeted delivery of a compound to a location in need of treatment, said nanodevice comprising a PAMAM dendrimer linked to the compound via a disulfide bond.
A nanodevice composition for localizing and delivering therapeutically active agents, said nanodevice comprising:
A nanodevice composition for localizing and delivering therapeutically active agents, said nanodevice comprising:
Dependencies are inferred from the claim text.