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US 8,883,417 B2Granted
Clinically intelligent diagnostic methods utilizing micromixers disposed in wells
AssigneeIntelligent Medical Devices, Inc.
InventorsAlice A. Jacobs, Boris Nikolic, Vineet Gupta
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Abstract
The invention relates to the clinically intelligent design of diagnostic devices (such as microarrays) and methods of making and using such devices in differential diagnoses of specific clinical symptoms or sets of symptoms. In one aspect, the devices include various probes used to perform parallel screening of a number of analytes. The probes are clustered on the devices based on known clinical presentations of symptoms associated with specific diseases and disorders.
Claims8
A method of determining a cause of one or more medical symptoms exhibited by a subject, the method comprising:
- (a) applying one or more biological samples from the subject to a multiplexed test, wherein the multiplexed test comprises a substrate having a surface, wherein the surface comprises a plurality of wells, wherein each well comprises:
- (i) a micromixer, wherein the micromixer is disposed in a bottom of the well and and
- (ii) one or more sets of probes, wherein each set of probes selectively interacts with a unique target and is attached to the bottom of the well around the micromixer
- (b) detecting interactions;
- and
- (c) analyzing the interactions to determine a cause of the one or more medical symptoms.
3 more elements
Dependencies are inferred from the claim text.