Treatment of pulmonary vascular remodeling with neprilysin
AssigneeThe Regents of the University of Colorado, a body corporate
InventorEdward C. Dempsey
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Abstract
The present invention relates to agonists of Neprilysin and their use in preventing and treating pulmonary vascular remodeling. Also described are diagnostic and screening applications stemming from the inventor's discovery that Neprilysin is expressed at reduced levels in disease tissues.
Claims15
A method for treating a subject with pulmonary vascular remodeling comprising administering to said subject a agent selected from (a) neprilysin, (b) an enzymatically active fragment of neprilysin comprising an intact peptidase domain, (c) an expression cassette comprising a polynucleotide encoding a neprilysin polypeptide or an enzymatically active fragment of neprilysin comprising an intact peptidase domain under the control of a promoter operable in eukaryotic cells.
Dependencies are inferred from the claim text.