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US 8,877,967 B2Granted
Compositions and methods for inhibition of cathepsins
AssigneesOXiGENE, Inc., Baylor University
InventorsDavid J. Chaplin, Kishore Kumar Gaddale Devanna, Erica Parker, Kevin G. Pinney, Jiangli Song, Mary Lynn Trawick
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Abstract
This invention is directed to compound of Formula I and methods of using these compounds in the treatment of conditions in which modulation of a cathepsin, particularly cathepsin K or cathepsin L, will be therapeutically useful.
Claims20
A compound of formula I:
- or a solvate or pharmaceutically acceptable salt thereof, wherein
- X is selected from the group consisting of C(═O), CH(OR6) and
- n is 0, 1, 2 or 3;
- m is 0, 1, 2 or 3;
- p is 0, 1, 2 or 3;
- R1 is hydrogen, C1-C3 alkyl, aryl and arylalkyl;
- R2 is hydrogen or C1-C3 alkyl;
- each R3 and R5 independently is selected from the group consisting of hydroxyl, C1-C3 alkyl, C1-C2 alkoxy, fluoro, and chloro;
- each R4 independently is selected from the group consisting of hydroxyl, C1-C6 alkyl, C1-C6 alkoxy, halo, amino, nitro, nitroso and acyl;
- and
- R6 is selected from the group consisting of hydrogen and methyl.
8 more elements
Dependencies are inferred from the claim text.