Methods for treating chronic obstructive pulmonary disease
AssigneeIndiana University Research and Technology Corporation
InventorsAnantha Shekhar, Philip L. Johnson
Life of this patent
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Abstract
Methods and compositions that down regulate the activity of orexins to treat panic disorder and panic-like responses associated with hypercapnic conditions are disclosed.
Claims5
A method of treating hypercapnia-induced anxiety associated with chronic obstructive pulmonary disease in an individual, the method comprising administering to the individual suffering from chronic obstructive pulmonary disease a composition comprising a therapeutically effective amount of an agent to down regulate the activity of an orexin, Orexin A, wherein the agent is an orexin receptor antagonist for orexin 1 receptors;
- wherein the effective amount treats hypercapnia-induced anxiety associated with chronic obstructive pulmonary disease in the individual wherein the effective amount treats hypercapnia-induced anxiety without altering the robust bradycardia response.
Dependencies are inferred from the claim text.