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US 8,877,763 B2Granted
Substituted pyridopyrimidine compounds and their use as FLT3 inhibitors
AssigneesGenosco, Oscotec Inc.
InventorsHong Woo Kim, Hee Kyu Lee, Ho-Juhn Song, Jaekyoo Lee, Jong Sung Koh, Jung-Ho Kim, Se Won Kim, In Yong Lee
Life of this patent
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Abstract
Compounds of Formula (I) and methods for inhibiting kinases, including spleen tyrosine kinases, are disclosed. Also disclosed are methods for treating a kinase-mediated disease or condition by administering to a subject a therapeutically effective amount of the compound of Formula (I).
Claims14
A compound represented by Formula (I):
- wherein:
- R1 is aryl, arylalkyl, C5-C6cycloalkyl or C5-C6cycloalkyl methyl optionally substituted with R3;
- R3 is independently fluoro, chloro, bromo, iodo, C1-C6alkyl, or CF3;
- X is F, Cl, Br, I, CH3, or CF3;
- Y is chloro, bromo, iodo, —C1-C3alkyl or phenyl;
- R2 is C4-C7heterocycloalkyl, wherein the C4-C7heterocycloalkyl has 1 or nitrogen atoms in the C4-C7 heterocycloalkyl ring, and is substituted at nitrogen with R5;
- and
- R5 is C1-C3alkyl or C(O)C1-C3alkyl, wherein the C1-C3alkyl group is optionally substituted with 1-3 fluorine atoms;
- or a pharmaceutically acceptable salt thereof.
6 more elements
Dependencies are inferred from the claim text.