Antibodies specific for Trop-2 and their uses
AssigneeRinat Neuroscience Corp.
InventorsShu-Hui Liu, Wei-Hsien Ho, Pavel Strop, Magdalena Grazyna Dorywalska, Arvind Rajpal, David Louis Shelton, Thomas-Toan Tran
Life of this patent
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Abstract
The present invention provides antibodies that specifically bind to trophoblast cell-surface antigen-2 (Trop-2). The invention further provides antibody conjugates comprising such antibodies, antibody encoding nucleic acids, and methods of obtaining such antibodies. The invention further relates to therapeutic methods for use of these antibodies and Trop-2 antibody conjugates for the treatment of a condition associated with Trop-2 expression (e.g., cancer), such as colon, esophageal, gastric, head and neck, lung, ovarian, or pancreatic cancer.
Claims26
An isolated antibody, or an antigen binding fragment thereof, which specifically binds to trophoblast cell-surface antigen-2 (Trop-2), wherein the antibody comprises
- (a) a heavy chain variable (VH) region comprising (i) a VH complementary determining region one (CDR1) comprising the sequence SYGVH (SEQ ID NO:
- 30), GGSISSY (SEQ ID NO:
- 36), or GGSISSYGVH (SEQ ID NO:
- 37);
- (ii) a VH CDR2 comprising the sequence VIWTX1GX2TDYNSALMX3, wherein X1 is G or S;
- X2 is S or V;
- X3 is S or G (SEQ ID NO:
- 49), or WTX1GX2, wherein X1 is G or S, X2 is S or V (SEQ ID NO:
- 50);
- and iii) a VH CDR3 comprising the sequence DGDYDRYTMDY (SEQ ID NO:
- 35);
- and
- (b) a light chain variable region (VL) comprising (i) a VL CDR1 comprising the sequence RASKSVSTSX1YSYMH, wherein X1 is G, L, or N (SEQ ID NO:
- 63);
- (ii) a VL CDR2 comprising the sequence LASNLES (SEQ ID NO:
- 55);
- and (iii) a VL CDR3 comprising the sequence QHSRELPYT (SEQ ID NO:
- 56).
An isolated antibody, or an antigen binding fragment thereof, which specifically binds to Trop-2, wherein the antibody comprises:
- a VH region comprising VH CDR1, VH CDR2, and VH CDR3 of the VH sequence shown in SEQ ID NO:
- 4 or 5;
- and
- a VL region comprising VL CDR1, VL CDR2, and VL CDR3 of the VL sequence shown in SEQ ID NO:3, 6, or 7.
Dependencies are inferred from the claim text.