Transgene delivering retrovirus targeting collagen exposed at site of tissue injury
AssigneeUniversity of Southern California
InventorsFrederick L. Hall, Erilinda Maria Gordon
Life of this patent
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Abstract
A viral or non-viral vector particle having a modified viral surface protein wherein the viral surface protein is modified to include a targeting polypeptide including a binding region which binds to an extracellular matrix component. Such vector particles are useful in delivering genes encoding therapeutic agents to cells located at the site of an exposed extracellular matrix component.
Claims18
A method of treating a disease associated with exposition of collagen of a host, comprising:
- directly or intravenously delivering to the host a retroviral particle comprising:
- (a) a modified viral envelope protein wherein the viral envelope protein includes a receptor binding region, wherein the receptor binding region is modified to include a collagen binding domain, and
- (b) at least one polynucleotide encoding a therapeutic polypeptide;
- wherein the viral particle binds to exposed collagen and expresses the therapeutic polypeptide, whereby said disease is treated.
A method of treating a disease in a host, wherein the disease is an inflammation or a connective tissue disorder, comprising:
- directly or intravenously delivering to the host a retroviral particle comprising:
- (a) a modified viral envelope protein wherein the viral envelope protein includes a receptor binding region, wherein the receptor binding region is modified to include a collagen binding domain;
- and
- (b) at least one polynucleotide encoding a therapeutic polypeptide;
- wherein the viral particle binds to collagen exposed at the site of the disease and expresses the therapeutic polypeptide, whereby said disease is treated.
A retroviral particle for treating a disease in a host, comprising a modified viral envelope protein, wherein the modified viral envelope protein includes a targeting polypeptide comprising a binding region which binds to collagen and at least one therapeutic polypeptide for treating the disease in the host.
Dependencies are inferred from the claim text.