Method for evaluating renal status by determining beta-2-glycoprotein 1

A method for evaluating renal status in a subject, comprising:

• performing an assay method configured to detect Beta-2-glycoprotein 1 by introducing a body fluid sample obtained from the subject into an assay instrument which (i) contacts all or a portion of the body fluid sample with a binding reagent which specifically binds for detection Beta-2-glycoprotein 1 and (ii) generates an assay result indicative of Beta-2-glycoprotein 1 binding to the binding reagent;
• correlating the assay result generated by the assay instrument to a likelihood that the subject is at risk of a future acute renal injury within 72 hours of the time at which the body fluid sample is obtained from the subject by using the assay result to assign the subject to a predetermined subpopulation of individuals having a known predisposition of a future acute renal injury within 72 hours;
• and
• treating the subject based on the predetermined subpopulation of individuals to which the patient is assigned, wherein the treatment comprises one or more of initiating renal replacement therapy, withdrawing delivery of compounds that are known to be damaging to the kidney, delaying or avoiding procedures that are known to be damaging to the kidney, and modifying diuretic administration.