Compounds, compositions, and methods for reducing or eliminating bitter taste

A composition comprising a bitter tastant and a compound according to Formula (I):

• or a comestibly or biologically acceptable salt or derivative thereof, or an enantiomer or diastereomer thereof,
• wherein, as valence and stability permit:
• R1 is absent or is selected from the group consisting of hydroxyl, C1-6alkoxy, and C1-6acyloxy;
• R2 is selected from the group consisting of hydrogen, C1-6alkyl, C2-6alkenyl, and C2-6alkynyl;
• R3 is selected from the group consisting of hydrogen and C1-6alkoxy;
• R4 is selected from the group consisting of hydroxyl, C1-6alkoxy, and C1-6acyloxy;
• or R3 and R4 together form ═O;
• wherein any of R1, R2, R3, and R4, independently, is optionally substituted with 1-3 substituents selected from the group consisting of C1-10alkyl, C1-10haloalkyl, halo, hydroxyl, carboxyl, C1-10alkoxycarbonyl, C2-10alkenyloxycarbonyl, C2-10alkynyloxycarbonyl, C1-10acyl, C1-10acylamino, C1-10acyloxy, C1-10carbonate, C1-10alkoxy, phenyloxy, phosphoryl, phosphate, phosphonate, phosphinate, amino, diC1-10alkylamino, monoC1-10alkylamino, C1-13amido, C1-10imino, C1-10carbamate, C1-10urea, cyano, nitro, azido, sulfhydryl, C1-10alkylthio, sulfate, sulfonate, sulfamoyl, sulfonamido, sulfonyl, C3-7-carbocyclyl, C3-7-carbocyclyl-C1-6alkyl, C1-6heterocyclyl, C1-6heterocyclyl-C1-6alkyl, phenyl, phenyl-C1-6alkyl, C1-5heteroaryl, and C1-5heteroaryl-C1-6alkyl;
• and wherein heterocyclic or heteroaromatic rings, independently for each occurrence, comprise 1-4 heteroatoms selected from N, O, and S;
• and
• m is 0-2;
• n is 0-2;
• p is 0-2;
• t is 0-2;
• wherein C1 and C6 in Formula (I) optionally are bonded together to form a 6-membered ring;
• and
• wherein all dotted bonds indicate optional carbon-carbon double bonds;
• wherein the composition is edible and wherein the bitter taste of a bitter tastant is reduced.