Salt forms of a xanthine compound
AssigneeBoehringer Ingelheim International GmbH
InventorsPeter Sieger, Waldemar Pfrengle
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Abstract
The present invention relates to novel salt forms of 1-[(4-methyl-quinazolin-2-yl)methyl]-3-methyl-7-(2-butyn-1-yl)-8-(3-(R)-amino-piperidin-1-yl)-xanthine, a DPP-4 inhibitor and their use in pharmaceutical compositions useful in the treatment of type 2, diabetes, as well as their production.
Claims10
A salt of 1-[(4-methyl-quinazolin-2-yl)methyl]-3-methyl-7-(2-butyn-1-yl)-8-(3-(R)-amino-piperidin-1-yl)-xanthine and a pharmaceutically acceptable acid in a 1:1 stoichiometry in the form of an organic solvate, hydrate, or mixed hydrate/organic solvate thereof.
An acid addition salt of 1-[(4-methyl-quinazolin-2-yl)-methyl]-3-methyl-7-(2-butyn-1-yl)-8-(3-(R)-amino-piperidin-1-yl)-xanthine with an acid selected from hydrochloric acid, hydrobromic acid, phosphoric acid, nitric acid, sulfuric acid, acetic acid, 2,2-dichloroacetic acid, adipic acid, D-ascorbic acid, L-ascorbic acid, D-aspartic acid, L-aspartic acid, benzenesulfonic acid, benzoic acid, 4-acetamido-benzoic acid, (+)-camphoric acid, (−)-camphoric acid, (+)-camphor-10-sulfonic, (−)-camphor-10-sulfonic, capric acid (decanoic acid), caproic acid (hexanoic acid), caprylic acid (octanoic acid), carbonic acid, cinnamic acid, citric acid, cyclamic acid, dodecylsulfuric acid, ethane-1,2-disulfonic acid, ethanesulfonic acid, 2-hydroxy-ethanesulfonic acid, formic acid, fumaric acid, galactaric acid, gentisic acid, D-glucoheptonic acid, L-glucoheptonic acid, D-gluconic acid, L-gluconic acid;
- D-glucuronic acid, L-glucuronic acid, glutamic acid, glutaric acid, 2-oxo-glutaric acid, glycerophosphoric acid, glycolic acid, hippuric acid, isobutyric acid, D-lactic acid, L-lactic acid, lactobionic acid, lauric acid, maleic acid, D-malic acid, L-malic acid, malonic acid, D-mandelic acid, L-mandelic acid, methanesulfonic acid, naphthalene-1,5-disulfonic acid, naphthalene-2-sulfonic acid, 1-hydroxy-2-naphthoic acid, nicotinic acid, oleic acid, orotic acid, oxalic acid, palmitic acid, pamoic acid (embonic acid), propionic acid, D-pyroglutamic acid, L-pyroglutamic acid, salicyclic acid, 4-aminosalicyclic acid, sebacic acid, stearic acid, succinic acid, D-tartaric acid, L-tartaric acid, thiocyanic acid, p-toluenesulfonic acid and undecylenic acid,
- in the form of an organic solvate, hydrate, or mixed hydrate/organic solvate thereof.
Dependencies are inferred from the claim text.