Rabies virus vector systems and compositions and methods thereof
AssigneeThe United States of America as represtented by the Secretary of the Department of Health and Human Services, Centers for Disease Control and Prevention
InventorsCharles E. Rupprecht, Xianfu Wu
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Abstract
Rabies Virus compositions and methods are provided. The full-length sequence of Rabies Virus strain Evelyn-Rokitnicki-Abelseth (ERA) is disclosed. A reverse genetics system for producing recombinant ERA virus and derivatives thereof is provided, along with compositions including ERA and/or ERA derivative strain viruses, nucleic acids and/or proteins. In some instances, the compositions are immunogenic compositions useful for the pre- or post-exposure treatment of Rabies Virus.
Claims20
A vector system comprising:
- a first vector comprising a full-length rabies virus antigenomic DNA, wherein the full-length antigenomic DNA comprises the nucleic acid sequence of SEQ ID NO:
- 17;
- and,
- a plurality of helper vectors comprising nucleic acids that encode at least one rabies virus strain ERA protein,
- wherein expression of the plurality of vectors in a transfected host cell results in production of a recombinant rabies virus.
A recombinant virus genome comprising the nucleic acid sequence as set forth in SEQ ID NO:
- 17.
A live rabies virus vaccine comprising at least one recombinant rabies virus genome, wherein the at least one recombinant rabies virus genome comprises the sequence shown in SEQ ID NO:
- 17.
Dependencies are inferred from the claim text.