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US 8,859,986 B2Granted
Ion generation using wetted porous material
AssigneePurdue Research Foundation
InventorsRobert G. Cooks, Ahmed M. Hamid, Alan K. Jarmusch, Zheng Ouyang
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Abstract
The invention generally relates to systems and methods for mass spectrometry analysis of microorganisms in samples.
Claims19
A system for analyzing an analyte from a liquid, the system comprising:
- a capture module, the module configured to capture an analyte from a liquid and generate ions of the analyte, wherein the capture module comprises a porous substrate operably coupled to a high voltage source;
- and
- a mass analyzer operably coupled to the capture module to receive the generated ions of the analyte.
A system for analyzing an analyte from a liquid, the system comprising:
- a liquid module comprising an inlet configured to receive a liquid that comprises an analyte, a vacuum port for a vacuum source, and a collection chamber operably coupled to the liquid inlet;
- a vacuum source operably coupled to the vacuum port on the liquid module;
- a porous substrate operably coupled to the inlet such that liquid that enters the inlet flows through the porous substrate and into the collection chamber, wherein the analyte in the liquid is retained by the porous substrate;
- a high voltage source operably coupled to the porous substrate;
- and
- a mass analyzer operably positioned to receive ions of the analyte generated from the porous substrate.
3 more elements
A method for analyzing an analyte from a liquid, the method comprising:
- flowing a liquid comprising an analyte through a porous substrate, wherein the analyte in the liquid is retained by the porous substrate after the liquid has been flowed through the porous substrate;
- applying high voltage to the porous substrate, thereby producing ions of the analyte;
- analyzing the ions.
Dependencies are inferred from the claim text.