US 8,859,615 B2 · Compounds, compositions and methods for reducing toxicity and treating or preventing diseases

Abstract

The present invention provides compounds of Formula (I), compositions comprising an effective amount of a compound of Formula (I), optionally with chemotherapeutic drugs such as a tubulin-binding drug, and methods of their use for reducing the toxicity of cytotoxic agents, treating or preventing cancer or a neuropathic disorder, inducing a chemoprotective phase II enzyme, DNA, or protein synthesis, enhancing the immune system, treating inflammation, improving and enhancing general health or well-being, and methods for making compounds of Formula (I).

Claims18

Dependent claims

A compound of the Formula

wherein:
each R1 is independently —H;
each R2 is independently —H, —C1-C6 alkyl, or —C(O)—C1-C6 alkyl, or both R2 groups combine to form —C(O)— or —C(Ra)(Ra)—, wherein each Ra is independently —H, —C1-C6 alkyl or phenyl;
R3 is —H;
and
Z is —C1-C10 alkyl;
or a pharmaceutically acceptable salt, solvate or hydrate thereof.

4 more elements

Dependencies are inferred from the claim text.

Facts

Application

13/061,508Filed 27 Aug 2009 · continuation in part

Priority

27 Aug 2008

Published

US 2011/0312904 A122 Dec 2011

Granted

14 Oct 2014

Term ends

Not estimatedThe source records don’t support an estimate.

Classification51 codes

C07C 33/048
Acyclic alcohols with carbon-to-carbon triple bonds: with double and triple bonds
A61K 31/047
Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates: having two or more hydroxy groups, e.g. sorbitol
A61K 31/075
Medicinal preparations containing organic active ingredients: ethers or acetals
A61K 31/165
Amides, e.g. hydroxamic acids: having aromatic rings, e.g. colchicine, atenolol, progabide

Family

PCT/US2008/074444Parent of this continuation-in-part · filed 27 Aug 2008

Application61/092,291Us provisional application · filed 27 Aug 2008

Application61/122,268Us provisional application · filed 12 Dec 2008

Application61/228,083Us provisional application · filed 23 Jul 2009

US 2011/0312904 A1Pre-grant publication · published 22 Dec 2011

US 8,859,615 B2This patent

From the US filing history. Foreign family members aren’t listed.

Compounds, compositions and methods for reducing toxicity and treating or preventing diseases

Life of this patent

Compounds, compositions and methods for reducing toxicity and treating or preventing diseases

Life of this patent

Abstract

Claims18