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US 8,859,237 B2Granted
Diguanylate cyclase method of producing the same and its use in the manufacture of cyclic-di-GMP and analogues thereof
AssigneeNanyang Technological University
InventorsZhao-Xun Liang, Feng Rao
Life of this patent
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Abstract
Described is a new stand-alone diguanylate cyclase polypeptide having a GGDEF motif and a mutated I-site that does not bind c-di-GMP. We demonstrate that the production yield of c-di-GMP and analogues was significantly increased by mutation of a conserved residue in the putative regulatory I-site.
Claims8
A diguanylate cyclase polypeptide according to a sequence selected from the group consisting of SEQ ID NO.:
- 2, SEQ ID NO.:
- 3, and SEQ ID NO.:
- 4.
Dependencies are inferred from the claim text.