Co-therapy for the treatment of epilepsy and related disorders
AssigneeJanssen Pharmaceutica NV
InventorsVirginia L. Smith-Swintosky, David F. McComsey, Michael H. Parker, Allen B. Reitz, Bruce E. Maryanoff
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Abstract
The present invention is directed to co-therapy for the treatment of epilepsy and related disorders comprising administering to a subject in need thereof, co-therapy with a therapeutically effective amount of a benzo-fused heterocycle sulfamide derivative and a therapeutically effective amount of one or more anticonvulsant and/or anti-epileptic agents.
Claims17
A method for treating epilepsy comprising administering to a subject in need thereof, co-therapy with a therapeutically effective amount of one or more anti-epileptic or anti-convulsant agents and a therapeutically effective amount of compound of formula (I)
- wherein
- R1 and R2 are each independently selected from the group consisting of hydrogen and lower alkyl;
- R4 is selected from the group consisting of hydrogen and lower alkyl;
- a is an integer from 1 to 2;
- is selected from the group consisting of
- wherein b is an integer from 0 to 4;
- and wherein c is an integer from 0 to 2;
- each R5 is independently selected from the group consisting of halogen and lower alkyl;
- provided that when
- then a is 1;
- or a pharmaceutically acceptable salt thereof.
A method for treating epilepsy or a related disorder, comprising administering to a subject in need thereof, co-therapy with a therapeutically effective amount of one or more anti-epileptic or anti-convulsant agents and a therapeutically effective amount of (2S)-(−)-N-(6-chloro-2,3-dihydro-benzo[1,4]dioxin-2ylmethyl)-sulfamide or a pharmaceutically acceptable salt thereof.
A method for the treatment of epilepsy comprising administering to a subject in need thereof, co-therapy with a therapeutically effective amount of one or more anticonvulsant or anti-epileptic agents and a therapeutically effective amount of a compound of formula
Dependencies are inferred from the claim text.