Recombinant proteins of Parapoxvirus ovis and pharmaceutical compositions therefrom
AssigneeAiCuris GmbH & Co. KG
InventorsOlaf Weber, Sonja Maria Tennagels, Angela Siegling, Tobias Schlapp, Andrew Allan Mercer, Stephen Bruce Fleming, Hans-Dieter Volk
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Abstract
The invention relates to polynucleotides coding for the PPVO viral genome, to fragments of the polynucleotides coding for the PPVO genome and to polynucleotides coding for individual open reading frames (ORFs) of the PPVO viral genome. The invention also relates to recombinant proteins expressed from the above mentioned polynucleotides and to fragments of said recombinant proteins, and to the use of said recombinant proteins or fragments for the preparation of pharmaceutical compositions.
Claims10
A method for inducing an immunomodulatory activity in a subject, comprising administering to the subject an individual recombinant protein encoded by a polynucleotide selected from the group consisting of:
- (i) a polynucleotide having the sequence consisting of nucleotide residues 31003 to 46845 of SEQ ID NO:1 (PPVO insert of VVOV 96),
- (ii) a polynucleotide having the sequence consisting of nucleotide residues 24056 to 33789 of SEQ ID NO:1 (PPVO insert of VVOV 97),
- (iii) a polynucleotide having the sequence consisting of nucleotide residues 82324 to 92502 of SEQ ID NO:1 (PPVO insert of VVOV 243),
- (iv) a polynucleotide having the sequence consisting of nucleotide residues 74804 to 88576 of SEQ ID NO:1 (PPVO insert of VVOV 285), and
- (v) a polynucleotide having the sequence consisting of nucleotide residues 102490 to 108393 of SEQ ID NO:1 (PPVO insert of VVOV 330),
- wherein the individual recombinam protein induces the immunomodulatory activity in the subject.
A method for inducing an immunomodulatory activity in a subject, comprising administering to the subject an individual recombinant virus containing a recombinant protein encoded by a polynucleotide selected from the group consisting of:
- (i) a polynucleotide having the sequence consisting of nucleotide residues 31003 to 46845 of SEQ ID NO:1 (PPVO insert of VVOV 96),
- (ii) a polynucleotide having the sequence consisting of nucleotide residues 24056 to 33789 of SEQ ID NO:1 (PPVO insert of VVOV 97),
- (iii) a polynucleotide having the sequence consisting of nucleotide residues 82324 to 92502 of SEQ ID NO:1 (PPVO insert of VVOV 243),
- (iv) a polynucleotide having the sequence consisting of nucleotide residues 74804 to 88576 of SEQ ID NO:1 (PPVO insert of VVOV 285), and
- (v) a polynucleotide having the sequence consisting of nucleotide residues 102490 to 108393 of SEQ ID NO:1 (PPVO insert of VVOV 330),
- wherein the recombinant protein induces the immunomodulatory activity in the subject.
Dependencies are inferred from the claim text.