Compression connection

A fluidic compression connection comprising:

• a first sealing device comprising:
• a first elongated body, having a first cylindrical bore extending from an entry opening at one end to an exit opening at the other end and having a fluid inlet at the entry opening and a first mating surface at the exit opening end;
• a second sealing device comprising:
• a second elongated body comprising an interchangeable plug-and-play consumable insert configured for automated connection which comprises a fluidic component, the second elongated body having a second cylindrical bore extending from an entry opening at one end to an exit opening at the other end and having a second mating surface at the entry opening end and a third mating surface at the exit opening end;
• a third sealing device comprising:
• a third elongated body, having a third cylindrical bore extending from an entry opening at one end to an exit opening at the other end and having a fluid outlet at the exit opening and a fourth mating surface at the entry opening end;
• at least one mechanical support;
• and
• a drive force mechanism, wherein the first mating surface opposes the second mating surface and the third mating surface opposes the fourth mating surface, and wherein the drive force mechanism is configured to apply a substantially axial drive force opposed by the at least one mechanical support, to compress the first, second, and third sealing devices and create a leak-resistant seal in the connection between the sealing devices.