Back to results
US 8,846,896 B2Granted
Methods of preparing substituted nucleotide analogs
AssigneesAlios BioPharma, Inc., Vertex Pharmaceuticals Incorporated
InventorsVladimir Serebryany, Jyanwei Liu, Leonid Beigelman, Young Chun Jung, Jamison Rose, Shereen Ibrahim, Cavan McKeon, Luigi Anzalone
Life of this patent
Estimating the term…
Abstract
Disclosed herein are methods of preparing a phosphorothioate nucleotide analog, which are useful in treating diseases and/or conditions such as viral infections.
Claims23
A method of preparing a compound of Formula (I):
- wherein the method comprises:
- coupling a compound of Formula (A) and a compound of Formula (B), wherein the —OH groups and —NH group of the compound of Formula (A) are unprotected during the coupling reaction.
Dependencies are inferred from the claim text.