Controlled release aural pressure modulator compositions and methods for the treatment of OTIC disorders

A pharmaceutical composition for otic administration comprising:

• (i) a therapeutically effective amount of a multiparticulate aural pressure modulating agent, or pharmaceutically acceptable salt thereof;
• (ii) a copolymer of polyoxyethylene and polyoxypropylene in an amount sufficient to provide a gelation temperature of between about 19° C. and about 42° C., a gelation viscosity between about 15,000 cP and about 1,000,000 cP;
• and a non-gelation viscosity that allows injection with a 18-31 gauge needle through the tympanic membrane on or near the round window membrane;
• and
• (iii) having an osmolarity of 100-500 mOsm/L;
• wherein the pharmaceutical composition for otic administration provides a sustained release of the aural pressure modulating agent to the inner ear for a period of at least 5 days after a single administration;
• wherein the aural pressure modulating agent is a vasopressin receptor modulator, prostaglandin receptor modulator, estrogen-related receptor beta modulator, a calcium channel blocker, or combinations thereof;
• provided that the aural pressure modulating agent is a non-corticosteroid aural pressure modulating agent.