Modulators of ATP-binding cassette transporters

A method of treating or lessening the severity of a disease in a patient, wherein said disease is pancreatic insufficiency or male infertility comprising the step of administering to said patient an effective amount of a compound of formula I:

• or a pharmaceutically acceptable salt thereof, wherein:
• Each R1 is independently an optionally substituted C1-6 aliphatic, an optionally substituted aryl, an optionally substituted C3-10 membered cycloaliphatic, carboxy, amido, amino, halo, or hydroxy, provided that at least one R1 is an optionally substituted aryl and said R1 is attached to the 3- or 4-position of the phenyl ring;
• R2 is hydrogen, an optionally substituted C1-6 aliphatic, an optionally substituted C3-6 cycloaliphatic, an optionally substituted phenyl, or an optionally substituted heteroaryl;
• Ring A is an optionally substituted cycloaliphatic;
• R4 is an optionally substituted benzo[d][1,3]dioxolyl ring;
• and
• n is 1, 2, 3, 4, or 5.