Use of a globin, a globin protomer or an extracellular hemoglobin obtained from the marine worm, Arenicola marina, for the preservation of organs, tissues, cells or cell cultures
AssigneesHemarina, Centre National De La Recherche Scientifique, Universite Pierre Et Marie Curie (Paris 6)
InventorsFranck Zal, Morgane Rousselot, Delphine Dutheil
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Abstract
The invention relates to the use of at least one globin and/or at least one globin protomer and/or at least one naturally extracellular native hemoglobin for the preservation of organs, tissues, organ and tissue cells and cell cultures.
Claims16
A method for the preservation of organs, tissues, or organ cells comprising perfusing said organs, tissues, or organ cells with a composition comprising at least one globin and/or at least one globin protomer and/or at least one naturally extracellular native hemoglobin of an invertebrate animal selected from a marine worm of the phylum Annelida, in combination with an organ storage medium, said medium being capable of protecting said organs, tissues, or cells from the deleterious effects of ischemia while satisfying the minimum metabolic needs of said organs, tissues, or cells wherein said marine worm is Arenicola marina.
A process for storage of organs, tissues, or organ cells, the process comprising static or dynamic perfusion storage of said organs, tissues, or cells comprising:
- perfusing said organs, tissues, or cells with a composition comprising at least one globin and/or at least one globin protomer and/or at least one naturally extracellular native hemoglobin of an invertebrate animal selected from a marine worm of the phylum Annelida, in combination with an organ storage medium, said medium being capable of protecting said organs, tissues, or cells from the deleterious effects of ischemia while satisfying the minimum metabolic needs of said organs, tissues, or cells wherein said marine worm is Arenicola marina.
A process for culturing organ cells or organ tissues of vertebrates or of invertebrates, the process comprising culturing said tissues or cells in the presence of a composition comprising at least one globin and/or at least one globin protomer and/or at least one naturally extracellular native hemoglobin of an invertebrate animal selected from a marine worm of the phylum Annelida, in combination with an organ storage medium or a cell culture medium, said medium being capable of protecting said tissues or cells from the deleterious effects of ischemia while satisfying the minimum metabolic needs of said tissues or cells wherein said marine worm is Arenicola marina.
Dependencies are inferred from the claim text.