Genetically modified organism for the production of lipids
AssigneeOrganobalance GmbH
InventorsChristine Lang, Andreas Raab
Life of this patent
Estimating the term…
Abstract
The invention provides an isolated genetically modified non-mammalian organism, wherein the activity of acyl-CoA: sterol acyltransferase/sterol O-acyltransferase (EC 2.3.1.26) and/or diacylglycerol acyltransferase/diacylglycerol O-acyltranferase (EC 2.3.1.20) and/or lecithin cholesterol acyl transferase/phospholipid: diacylglycerol acyltransferase (EC 2.3.1.158) and/or acyl CoA-wax alcohol acyltransferase (EC 2.3.1.75) is reduced or abolished in comparison with a corresponding wildtype organism, methods of use of such an organism, shuttle vehicles for making such an organism and methods for producing such an organism.
Claims4
An isolated genetically modified non-mammalian organism, wherein the activity of acyl-CoA:
- sterol acyltransferase/sterol O-acyltransferase (EC 2.3.1.26) and/or diacylglycerol acyltransferase/diacylglycerol O-acyltranferase (EC 2.3.1.20) is reduced or abolished in comparison with a corresponding wildtype organism, and wherein the activity of HMG-CoA-reductase (3-hydroxy-3-methyl-glutaryl-Coenzyme-A-reductase, EC1.1.1.34), is increased in comparison with the corresponding wildtype organism, and wherein the activities and/or amounts of heme-activated protein HAP4p and/or SNF1-activated kinase SAKI p are increased and/or wherein the activities and/or amounts of regenerating islet-derived 1 pseudogene REGI p and/or few lipid dropplets protein 1 FLDI p are decreased or abolished.
Dependencies are inferred from the claim text.