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US 8,835,654 B2Granted
Method and compositions for treating amyloid-related diseases
AssigneeBHI Limited Partnership
InventorsXianqi Kong, Xinfu Wu, Abderrahim Bouzide, Isabelle Valade, David Migneault, Francine Gervais, Daniel Delorme, Benoit Bachand, Mohamed Atfani, Sophie Levesque, Bita Samim
Life of this patent
Estimating the term…
Abstract
Methods, compounds, pharmaceutical compositions and kits are described for treating or preventing amyloid-related disease.
Claims6
A compound of formula XII
- wherein:
- Rh is hydrogen, benzyl, aryl-alkyl, aryl, or alkyl;
- Ri is hydrogen, substituted or unsubstituted aryl, substituted or unsubstituted benzyl, alkenyl, carbocyclic, heterocyclic, or together with Rj, Rk or Rm may be linked to form a ring structure;
- Rj, Rk, Rm, Rn, and Ro are each independently hydrogen, substituted or unsubstituted aryl, substituted or unsubstituted benzyl, alkyl, alkenyl, carbocyclic, heterocyclic, absent or together may be linked to form a ring structure;
- X+ is hydrogen, a cationic group, or an ester-forming group;
- t1 and t2 are each single or double bonds, provided that both t1 and t2 are not both double bonds;
- provided that at least one of (i), (ii), or (iii) applies:
- (i) Rh is an aryl-alkyl or aryl group represented by a thiophenyl-alkyl, benzothiophenyl-alkyl, thiophenyl, or benzothiophenyl group;
- (ii) at least one of Rj, Rk, Rm, Rn and Ro is an alkyl group substituted with a thiophenyl or benzothiophenyl group;
- or
- (iii) at least one of Rj, Rk, Rm, Rn, or Ro is an aryl group represented by thiophenyl or benzothiophenyl group;
- or a pharmaceutically acceptable salt, ester or prodrug thereof.
9 more elements
A compound of Formula X:
- wherein:
- Ra is a thiophenyl or benzothiophenyl group;
- Rb and Rc are each selected independently from hydrogen, substituted or unsubstituted alkyl, alkenyl, alkynyl, cycloalkyl, CONH2, or Rb, Rc and the carbon atom they are attached to can form a substituted or unsubstituted cyclic structure of 4 to 8-membered ring or a fused ring system;
- and
- X+ is hydrogen, a cationic group, or an ester-forming group;
- or a pharmaceutically acceptable salt, ester or prodrug thereof.
3 more elements
A compound wherein said compound is:
- or a pharmaceutically acceptable salt, ester, or prodrug thereof.
Dependencies are inferred from the claim text.