US 8,835,384 B2Granted

Compositions and methods for obtaining cells to treat heart tissue

AssigneeMayo Foundation for Medical Education and Research

InventorsAndre Terzic, Atta Behfar

Life of this patent

Estimating the term…

Abstract

This document relates to compositions containing cardiogenic factors, to methods to obtain cells by culturing initial cells in the presence of such factors; and methods of administering the obtained cells to heart tissue.

Claims5

Dependent claims

A method for increasing expression of Nkx2.5 mRNA, GATA 6 mRNA, and Fog 1 mRNA within human mesenchymal stem cells, wherein said method comprises culturing human mesenchymal stem cells in the presence of a composition comprising TGFβ-1, BMP4, α-thrombin, Cardiotrophin, and Cardiogenol C.

Dependencies are inferred from the claim text.

Facts

Application: 12/994,626Filed 20 May 2009 · continuation in part
Priority: 27 May 2008
Published: US 2011/0117065 A119 May 2011
Granted: 16 Sep 2014
Term ends: Not estimatedThe source records don’t support an estimate.

Classification29 codes

C12N 5/0657
Cells of skeletal and connective tissues; Mesenchyme: cardiomyocytes; Heart cells
A61K 31/505
Having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines: pyrimidines; Hydrogenated…
A61K 31/529
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim: forming part of bridged ring systems
A61K 35/28
Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically…:…

Family

PCT/US2008/064895Parent of this continuation-in-part · filed 27 May 2008
US 2011/0117065 A1Pre-grant publication · published 19 May 2011
US 8,835,384 B2This patent

From the US filing history. Foreign family members aren’t listed.

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