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AssigneesBaxter International Inc., Baxter Healthcare S.A.
InventorsJohann Odar, Abolghassem Sepehrnia, Ralph Schachtler, Axel W. Stemberger
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A method of using a substantially non-porous equine collagen foil to repair and regenerate dura mater tissue of mammals when the dura mater tissue is damaged as a result of injury, tumors, surgery, and the like. The non-porous equine collagen foil comprises collagen fibrils which provides a replacement dura mater composition that is elastic, liquid-tight, and which has a high tensile strength. The non-porous equine collagen foil is furthermore resorbable and provides a biomatrix, wherein a neodura is rapidly formed which becomes indistinguishable from the autologous dura mater in a matter of weeks. The process for making the equine collagen foil reduces the likelihood of disease transmission.
A method of repairing and regenerating dura mater tissue in a mammal comprising attaching a collagen foil to the dura matter tissue, wherein the collagen foil comprises a non-naturally occurring biomatrix of multiple layers of precipitated collagen fibrils having a diameter of between 10 to 300 nanometers that are not cross-linked by chemicals or radiation, wherein the biomatrix comprises pores that are isolated from one another and are not interconnected in a manner which traverses the collagen foil, wherein the multiple layers of precipitated collagen fibrils form stacked collagen fibril sheets packed tightly together with interstices there between, and wherein the multiple layers of precipitated collagen fibrils of the collagen foil have an ultimate tensile force of between 0.5 Newtons/cm-strip and 30 Newtons/cm-strip.
A method of repairing and regenerating dura mater tissue in a mammal comprising attaching a collagen foil to the dura matter tissue, wherein the collagen foil comprises a non-naturally occurring biomatrix of multiple layers of precipitated collagen fibrils, wherein the biomatrix comprises pores that are isolated from one another and are not interconnected in a manner which traverses the collagen foil, wherein the multiple layers of precipitated collagen fibrils form stacked collagen fibril sheets packed tightly together with interstices there between, and wherein the multiple layers of precipitated collagen fibrils of the collagen foil have an ultimate tensile force of between 0.5 Newtons/cm-strip and 30 Newtons/cm-strip.
A method of repairing and regenerating dura mater tissue in a mammal comprising contacting a collagen foil to the dura matter tissue and allowing the collagen foil to be held in place in a desired implantation site by a natural adhesion that occurs between the collagen foil and the dura mater tissues, wherein the collagen foil comprises a non-naturally occurring biomatrix of multiple layers of precipitated collagen fibrils, wherein the biomatrix comprises pores that are isolated from one another and are not interconnected in a manner which traverses the collagen foil, wherein the multiple layers of precipitated collagen fibrils form stacked collagen fibril sheets packed tightly together with interstices there between.
Dependencies are inferred from the claim text.